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PLASMIDS | |
Name: | pSK1 |
DSM No.: | 9385 dsm-9385 dsm9385 dsm 9385 pSK1 |
History: | <- R.A. Skurray, Univ. Sydney |
Mol. weight: | 28.4 kb |
Marker: | Acr, Ebr, Gmr, Kmr, Qar, Tbr, Tmr |
Remarks: | Multiresistance plasmid encoding resistance to the aminoglycoside antibiotics gentamicin, tobramycin and kanamycin and to trimethoprim and carrying the qacA determinant responsible for linked resistance to acriflavine (Acr), ethidium bromide (Ebr), quaternary ammonium compounds (Qar), propamidine isothianate (Pir), and diamidinodiphenylamine dihydrochloride (Ddr). The qacA gene is widespread on S. aureus resistance plasmids. PSK1 is the prototype aminoglycoside resistance plasmid and represents a family of structurally related plasmids detected in Australian clinical isolates of coagulase-negative multiresistant S. aureus: restriction mapping identified identity of the qacA region of pSK1 with these other multiresistant plasmids. The qacA-determined phenotype was shown to be due to an efflux system with altered cell permeability. QacA affords protection against many commonly used clinical antiseptic/disinfectant formulations. The aminoglycoside antibiotic resistances are encoded by the 4.7 kb transposon Tn4001. |
Distributed in: | Staphylococcus aureus subsp. aureus SK982 |
Cultivation conditions: | Medium 1, 37°C |
Literature: | 6241, 6242, 6243 |
Risk group: | 2 (classification according to German TRBA) |
Restrictions: | Act dealing with the prevention & control of infectious diseases in man (Infektionsschutzgesetz), Category A1 German war weapons control act, Category B1 |
Country: | country of origin unknown |
Date of sampling: | before 24.07.1995 |
Nagoya Protocol Restrictions: | There are NO known Nagoya protocol restrictions for this strain. |
Supplied as: | Delivery form | | Organization type | | | | Profit | | Non-Profit | | | Freeze Dried | | 100,- € | | 100,- € | | Active culture on request | | 240,- € | | 240,- € | |
Price category 1 strain. Please see price list for freight and handling charges |
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